| 3. Jornada | 20.06.2021 | D.C. United | - | Inter Miami CF | 1:0 | ||||
| 3. Jornada | 24.06.2021 | CF Montréal | - | D.C. United | 0:0 | ||||
| 4. Jornada | 03.07.2021 | D.C. United | - | Toronto FC | 7:1 |  |
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| 4. Jornada | 18.07.2021 | Philadelphia Union | - | D.C. United | 2:1 | ||||
| 4. Jornada | 22.07.2021 | Chicago Fire | - | D.C. United | 2:2 | ||||
| 5. Jornada | 05.08.2021 | Columbus Crew | - | D.C. United | 2:4 | ||||
| 5. Jornada | 19.08.2021 | New England Revolution | - | D.C. United | 3:2 | ||||
| 5. Jornada | 22.08.2021 | D.C. United | - | Atlanta United FC | 1:2 | ||||
| 6. Jornada | 18.09.2021 | Atlanta United FC | - | D.C. United | 3:2 | ||||
| 6. Jornada | 26.09.2021 | D.C. United | - | FC Cincinnati | 4:2 | ||||
| 7. Jornada | 24.10.2021 | New York City FC | - | D.C. United | 6:0 |
Estados Unidos