| 2. Jornada | 02.08.2010 | Oriente Petrolero | - | Real Potosí | 3:1 | ||||
| 4. Jornada | 14.08.2010 | Bolívar | - | Real Potosí | 2:0 | ||||
| 5. Jornada | 21.08.2010 | Real Potosí | - | Real Mamoré | 4:0 | ||||
| 3. Jornada | 26.08.2010 | Real Potosí | - | Club Aurora | 2:1 |  |
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| 6. Jornada | 28.08.2010 | Club San José | - | Real Potosí | 2:3 | |
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| 7. Jornada | 05.09.2010 | Real Potosí | - | Universitario de Sucre | 1:1 | ||||
| 8. Jornada | 09.09.2010 | Blooming | - | Real Potosí | 2:2 | ||||
| 9. Jornada | 12.09.2010 | Real Potosí | - | Jorge Wilstermann | 2:1 | ||||
| 10. Jornada | 19.09.2010 | The Strongest | - | Real Potosí | 4:2 | ||||
| 11. Jornada | 26.09.2010 | Real Potosí | - | CD Guabirá | 4:0 | ||||
| 12. Jornada | 02.10.2010 | Real Potosí | - | La Paz FC | 2:3 | ||||
| 14. Jornada | 10.10.2010 | Club Aurora | - | Real Potosí | 0:2 | ||||
| 15. Jornada | 17.10.2010 | Real Potosí | - | Bolívar | 1:1 | ||||
| 16. Jornada | 24.10.2010 | Real Mamoré | - | Real Potosí | 2:1 |  |
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| 17. Jornada | 04.11.2010 | Real Potosí | - | Club San José | 1:3 | ||||
| 19. Jornada | 07.11.2010 | Real Potosí | - | Blooming | 3:0 | ||||
| 20. Jornada | 14.11.2010 | Jorge Wilstermann | - | Real Potosí | 1:1 | ||||
| 21. Jornada | 21.11.2010 | Real Potosí | - | The Strongest | 2:3 |
Argentina