| 3. Jornada | 26.01.2025 | Santos Laguna | - | CF América | 1:4 | ||||
| 5. Jornada | 03.02.2025 | Santos Laguna | - | Puebla FC | 0:2 | ||||
| 6. Jornada | 08.02.2025 | Club Necaxa | - | Santos Laguna | 3:2 | ||||
| 7. Jornada | 15.02.2025 | Mazatlán FC | - | Santos Laguna | 1:1 | ||||
| 9. Jornada | 20.02.2025 | Santos Laguna | - | Cruz Azul | 0:1 | ||||
| 12. Jornada | 16.03.2025 | UANL Tigres | - | Santos Laguna | 3:0 | ||||
| 16. Jornada | 17.04.2025 | Pumas UNAM | - | Santos Laguna | 2:0 |
México