| 3. Jornada | 23.07.2022 | Gualaceo SC | - | Deportivo Cuenca | 0:0 | ||||
| 4. Jornada | 01.08.2022 | Emelec | - | Gualaceo SC | 2:1 | ||||
| 5. Jornada | 09.08.2022 | Gualaceo SC | - | 9 de Octubre | 1:0 | ||||
| 6. Jornada | 13.08.2022 | Independiente del Valle | - | Gualaceo SC | 2:0 | ||||
| 7. Jornada | 20.08.2022 | Gualaceo SC | - | Técnico Universitario | 0:3 | ||||
| 8. Jornada | 28.08.2022 | Mushuc Runa | - | Gualaceo SC | 2:0 | ||||
| 9. Jornada | 04.09.2022 | Gualaceo SC | - | Barcelona | 2:1 |  |
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| 10. Jornada | 10.09.2022 | Orense SC | - | Gualaceo SC | 4:1 | ||||
| 11. Jornada | 17.09.2022 | Macará | - | Gualaceo SC | 1:1 |
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