| 1. Jornada | 31.07.2021 | CSD Municipal | - | Deportivo Guastatoya | 1:0 | ||||
| 2. Jornada | 07.08.2021 | Santa Lucía | - | CSD Municipal | 1:1 | ||||
| 3. Jornada | 11.08.2021 | CSD Municipal | - | Deportivo Malacateco | 4:0 |  |
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| 4. Jornada | 14.08.2021 | CSD Municipal | - | Iztapa | 2:2 | ||||
| 5. Jornada | 22.08.2021 | Xelaju MC | - | CSD Municipal | 0:0 | ||||
| 6. Jornada | 25.08.2021 | CSD Municipal | - | Sololá FC | 2:3 |  |
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| 7. Jornada | 29.08.2021 | Nueva Concepción | - | CSD Municipal | 0:2 | |
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| 9. Jornada | 11.09.2021 | Comunicaciones | - | CSD Municipal | 2:1 | ||||
| 10. Jornada | 18.09.2021 | CSD Municipal | - | Cobán Imperial | 2:1 | |
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| 8. Jornada | 29.09.2021 | CSD Municipal | - | Achuapa | 1:0 | ||||
| 12. Jornada | 03.10.2021 | Deportivo Guastatoya | - | CSD Municipal | 1:0 | ||||
| 11. Jornada | 14.10.2021 | Antigua GFC | - | CSD Municipal | 1:1 | ||||
| 15. Jornada | 23.10.2021 | Iztapa | - | CSD Municipal | 1:0 | |
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| 19. Jornada | 14.11.2021 | Achuapa | - | CSD Municipal | 0:1 | ||||
| 20. Jornada | 20.11.2021 | CSD Municipal | - | Comunicaciones | 0:0 | ||||
| 21. Jornada | 28.11.2021 | Cobán Imperial | - | CSD Municipal | 0:1 | |
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| 22. Jornada | 05.12.2021 | CSD Municipal | - | Antigua GFC | 1:0 |
Argentina