| 3. Jornada | 17.04.2022 | Minnesota United FC | - | Colorado Rapids | 3:1 | ||||
| 3. Jornada | 24.04.2022 | Colorado Rapids | - | Charlotte FC | 0:0 | ||||
| 4. Jornada | 01.05.2022 | Colorado Rapids | - | Portland Timbers | 2:0 | ||||
| 4. Jornada | 08.05.2022 | San Jose Earthquakes | - | Colorado Rapids | 1:0 | ||||
| 4. Jornada | 23.05.2022 | Colorado Rapids | - | Seattle Sounders | 1:0 | ||||
| 6. Jornada | 24.07.2022 | Seattle Sounders | - | Colorado Rapids | 2:1 |  |
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| 7. Jornada | 03.08.2022 | New York RB | - | Colorado Rapids | 4:5 | |
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| 7. Jornada | 07.08.2022 | Colorado Rapids | - | Minnesota United FC | 4:3 | ||||
| 7. Jornada | 18.08.2022 | Vancouver Whitecaps | - | Colorado Rapids | 2:1 | ||||
| 7. Jornada | 28.08.2022 | Philadelphia Union | - | Colorado Rapids | 6:0 |  |
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| 8. Jornada | 11.09.2022 | Colorado Rapids | - | Vancouver Whitecaps | 3:1 | ||||
| 9. Jornada | 01.10.2022 | Colorado Rapids | - | FC Dallas | 1:0 |  |
Ecuador