| 1. Jornada | 24.07.2021 | FC Juárez | - | Deportivo Toluca | 1:3 | ||||
| 2. Jornada | 01.08.2021 | Atlas Guadalajara | - | FC Juárez | 2:0 | ||||
| 3. Jornada | 08.08.2021 | Deportivo Guadalajara | - | FC Juárez | 2:2 | ||||
| 4. Jornada | 14.08.2021 | FC Juárez | - | Club Tijuana | 1:1 | ||||
| 5. Jornada | 19.08.2021 | FC Juárez | - | CF América | 1:2 | ||||
| 6. Jornada | 23.08.2021 | Club Necaxa | - | FC Juárez | 1:0 | ||||
| 7. Jornada | 30.08.2021 | Santos Laguna | - | FC Juárez | 2:0 | ||||
| 8. Jornada | 11.09.2021 | FC Juárez | - | Cruz Azul | 2:1 |  |
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| 9. Jornada | 19.09.2021 | Club León | - | FC Juárez | 0:1 | ||||
| 14. Jornada | 22.09.2021 | FC Juárez | - | Atlético San Luis | 1:0 |  |
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| 12. Jornada | 02.10.2021 | FC Juárez | - | CF Monterrey | 3:1 | ||||
| 10. Jornada | 09.10.2021 | FC Juárez | - | Gallos Blancos | 0:0 | ||||
| 13. Jornada | 17.10.2021 | Pumas UNAM | - | FC Juárez | 1:0 | ||||
| 15. Jornada | 25.10.2021 | CF Pachuca | - | FC Juárez | 1:1 | ||||
| 16. Jornada | 30.10.2021 | FC Juárez | - | Puebla FC | 0:2 | ||||
| 17. Jornada | 07.11.2021 | UANL Tigres | - | FC Juárez | 3:0 |  |
Paraguay