| 1. Jornada | 17.05.2021 | Cerrito | - | River Plate | 3:1 | ||||
| 2. Jornada | 24.05.2021 | River Plate | - | Liverpool | 3:2 | ||||
| 9. Jornada | 03.07.2021 | River Plate | - | Boston River | 1:1 |  |
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| 10. Jornada | 10.07.2021 | Montevideo Wanderers | - | River Plate | 1:2 | ||||
| 11. Jornada | 17.07.2021 | River Plate | - | Rentistas | 0:0 | ||||
| 12. Jornada | 01.08.2021 | Peñarol | - | River Plate | 2:0 | |
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| 13. Jornada | 07.08.2021 | River Plate | - | Montevideo City Torque | 3:3 | ||||
| 14. Jornada | 15.08.2021 | Villa Española | - | River Plate | 1:1 |
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