| 5. Jornada | 02.01.2021 | ENPPI | - | Zamalek | 1:2 | ||||
| 7. Jornada | 12.01.2021 | Al Masry Club | - | Zamalek | 0:1 | ||||
| 14. Jornada | 01.03.2021 | Wadi Degla SC | - | Zamalek | 0:0 | ||||
| 16. Jornada | 22.04.2021 | El Entag El Harby | - | Zamalek | 0:2 |  |
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| 17. Jornada | 26.04.2021 | Zamalek | - | National Bank SC | 4:1 | ||||
| 18. Jornada | 29.04.2021 | Zamalek | - | Al Mokawloon | 2:2 | ||||
| 19. Jornada | 02.05.2021 | Zamalek | - | Pyramids FC | 1:1 | ||||
| 20. Jornada | 06.05.2021 | Zamalek | - | Smouha Sporting Club | 2:1 | ||||
| 21. Jornada | 10.05.2021 | Al Ahly SC | - | Zamalek | 1:1 | ||||
| 23. Jornada | 20.05.2021 | Zamalek | - | Tala'ea El Gaish SC | 2:1 | ||||
| 24. Jornada | 24.05.2021 | Zamalek | - | Al Masry Club | 3:2 | |
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| 26. Jornada | 17.06.2021 | Zamalek | - | Aswan SC | 3:0 | ||||
| 27. Jornada | 28.06.2021 | Misr lel-Maqasah SC | - | Zamalek | 0:1 | ||||
| 28. Jornada | 07.08.2021 | Zamalek | - | Ghazl Al Mehalla | 3:0 | ||||
| 29. Jornada | 10.08.2021 | Ittihad El Iskandary | - | Zamalek | 1:2 | ||||
| 30. Jornada | 14.08.2021 | Ismaily | - | Zamalek | 0:2 | ||||
| 31. Jornada | 17.08.2021 | Zamalek | - | Wadi Degla SC | 1:0 | ||||
| 32. Jornada | 20.08.2021 | Ceramica Cleopatra | - | Zamalek | 1:2 | ||||
| 33. Jornada | 24.08.2021 | Zamalek | - | El Entag El Harby | 2:0 |
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