| 5. Jornada | 20.03.2022 | Mushuc Runa | - | Barcelona | 1:1 | ||||
| 7. Jornada | 09.04.2022 | Mushuc Runa | - | Delfín SC | 1:2 | ||||
| 8. Jornada | 16.04.2022 | Gualaceo SC | - | Mushuc Runa | 3:2 | ||||
| 9. Jornada | 21.04.2022 | Mushuc Runa | - | Macará | 0:0 |  |
|||
| 10. Jornada | 24.04.2022 | LDU Quito | - | Mushuc Runa | 3:2 | ||||
| 11. Jornada | 30.04.2022 | Mushuc Runa | - | Guayaquil City | 2:0 | |
|||
| 12. Jornada | 08.05.2022 | Emelec | - | Mushuc Runa | 4:0 | ||||
| 13. Jornada | 14.05.2022 | Mushuc Runa | - | Aucas | 1:1 | |
|||
| 14. Jornada | 23.05.2022 | Independiente del Valle | - | Mushuc Runa | 0:1 | ||||
| 15. Jornada | 28.05.2022 | Mushuc Runa | - | Deportivo Cuenca | 1:0 |
Ecuador