| 1. Jornada | 21.08.2021 | King's Lynn | - | Southend United | 0:1 | ||||
| 2. Jornada | 28.08.2021 | Southend United | - | Stockport County | 0:1 | ||||
| 3. Jornada | 30.08.2021 | Wealdstone FC | - | Southend United | 0:0 | ||||
| 4. Jornada | 04.09.2021 | Southend United | - | Wrexham AFC | 2:2 | ||||
| 5. Jornada | 11.09.2021 | Halifax Town | - | Southend United | 3:1 |  |
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| 12. Jornada | 23.10.2021 | Dagenham & Redbridge | - | Southend United | 3:0 | ||||
| 13. Jornada | 02.11.2021 | Southend United | - | Dover Athletic | 4:1 | ||||
| 15. Jornada | 13.11.2021 | Southend United | - | Woking FC | 0:2 | ||||
| 18. Jornada | 27.11.2021 | Altrincham FC | - | Southend United | 1:2 | |
Inglaterra