| 1. Jornada | 07.02.2016 | Sud América | - | Defensor Sporting | 2:0 | ||||
| 2. Jornada | 14.02.2016 | Defensor Sporting | - | Racing | 1:3 | ||||
| 3. Jornada | 22.02.2016 | Peñarol | - | Defensor Sporting | 5:1 | ||||
| 4. Jornada | 28.02.2016 | Defensor Sporting | - | Danubio | 3:2 | ||||
| 5. Jornada | 06.03.2016 | Rentistas | - | Defensor Sporting | 0:1 | ||||
| 6. Jornada | 21.03.2016 | Defensor Sporting | - | Liverpool | 1:2 | ||||
| 8. Jornada | 11.04.2016 | Defensor Sporting | - | Nacional | 2:4 |  |
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| 9. Jornada | 23.04.2016 | Montevideo Wanderers | - | Defensor Sporting | 0:0 | ||||
| 11. Jornada | 08.05.2016 | Juventud de Las Piedras | - | Defensor Sporting | 2:1 | ||||
| 12. Jornada | 14.05.2016 | Defensor Sporting | - | CA Cerro | 1:0 | |
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| 13. Jornada | 22.05.2016 | El Tanque Sisley | - | Defensor Sporting | 5:6 | |
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| 14. Jornada | 29.05.2016 | River Plate | - | Defensor Sporting | 1:2 | ||||
| 15. Jornada | 05.06.2016 | Defensor Sporting | - | Fénix | 1:0 |
Uruguay