| 1. Jornada | 13.03.2021 | San Telmo | - | Barracas Central | 1:1 | ||||
| 2. Jornada | 22.03.2021 | Independiente Rivadavia | - | San Telmo | 4:3 |  |
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| 3. Jornada | 28.03.2021 | San Telmo | - | Atlético Rafaela | 0:0 | |
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| 4. Jornada | 04.04.2021 | Guillermo Brown | - | San Telmo | 1:2 | ||||
| 5. Jornada | 11.04.2021 | San Telmo | - | Brown de Adrogué | 2:1 | ||||
| 6. Jornada | 18.04.2021 | San Martín de San Juan | - | San Telmo | 5:0 | |
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| 8. Jornada | 02.05.2021 | San Telmo | - | All Boys | 1:1 | ||||
| 17. Jornada | 19.07.2021 | Instituto de Córdoba | - | San Telmo | 1:0 | ||||
| 18. Jornada | 24.07.2021 | Barracas Central | - | San Telmo | 3:2 | ||||
| 19. Jornada | 01.08.2021 | San Telmo | - | Independiente Rivadavia | 1:0 | ||||
| 20. Jornada | 06.08.2021 | Atlético Rafaela | - | San Telmo | 2:2 | |
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| 22. Jornada | 21.08.2021 | Brown de Adrogué | - | San Telmo | 2:2 | ||||
| 27. Jornada | 25.09.2021 | Ramón Santamarina | - | San Telmo | 0:2 | ||||
| 29. Jornada | 08.10.2021 | Güemes de SdE | - | San Telmo | 1:1 | ||||
| 34. Jornada | 15.11.2021 | San Telmo | - | Instituto de Córdoba | 0:1 |
Argentina