| 2. Jornada | 16.01.2022 | Club Tijuana [Sub 20] | - | Club León [Sub 20] | 1:2 | ||||
| 1. Jornada | 19.01.2022 | Club León [Sub 20] | - | Atlas Guadalajara [Sub 20] | 1:1 |  |
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| 3. Jornada | 22.01.2022 | Club León [Sub 20] | - | CF Pachuca [Sub 20] | 4:3 | ||||
| 4. Jornada | 07.02.2022 | Club León [Sub 20] | - | Cruz Azul [Sub 20] | 2:1 | ||||
| 5. Jornada | 13.02.2022 | Pumas UNAM [Sub 20] | - | Club León [Sub 20] | 2:1 | ||||
| 6. Jornada | 19.02.2022 | Club León [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 3:0 | |
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| 7. Jornada | 25.02.2022 | Club Necaxa [Sub 20] | - | Club León [Sub 20] | 0:3 | ||||
| 8. Jornada | 01.03.2022 | Club León [Sub 20] | - | CF Monterrey [Sub 20] | 1:2 |  |
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| 9. Jornada | 04.03.2022 | FC Juárez [Sub 20] | - | Club León [Sub 20] | 0:1 | |
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| 10. Jornada | 12.03.2022 | Club León [Sub 20] | - | UANL Tigres [Sub 20] | 2:1 | ||||
| 15. Jornada | 20.04.2022 | CF América [Sub 20] | - | Club León [Sub 20] | 2:1 | ||||
| 17. Jornada | 01.05.2022 | Club León [Sub 20] | - | Deportivo Toluca [Sub 20] | 3:1 |
México