| 1. Jornada | 09.01.2022 | Deportivo Guadalajara [Sub 20] | - | Mazatlán FC [Sub 20] | 1:0 | ||||
| 6. Jornada | 19.02.2022 | Club León [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 3:0 | ||||
| 8. Jornada | 02.03.2022 | Atlético San Luis [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 2:3 | ||||
| 10. Jornada | 12.03.2022 | Deportivo Guadalajara [Sub 20] | - | CF América [Sub 20] | 0:2 | ||||
| 4. Jornada | 29.03.2022 | FC Juárez [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:2 | ||||
| 17. Jornada | 29.04.2022 | Club Necaxa [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 0:3 |
México