| 3. Jornada | 01.02.2021 | Real Cartagena | - | Barranquilla FC | 1:0 | ||||
| 4. Jornada | 06.02.2021 | Barranquilla FC | - | Real Santander | 1:0 | ||||
| 5. Jornada | 11.02.2021 | Bogotá FC | - | Barranquilla FC | 1:0 |  |
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| 6. Jornada | 15.02.2021 | Barranquilla FC | - | Fortaleza FC | 1:2 | |
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| 7. Jornada | 22.02.2021 | Leones FC | - | Barranquilla FC | 2:1 | |
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| 8. Jornada | 27.02.2021 | Barranquilla FC | - | Atlético Huila | 0:0 | ||||
| 9. Jornada | 04.03.2021 | Cortuluá | - | Barranquilla FC | 1:1 | ||||
| 10. Jornada | 07.03.2021 | Barranquilla FC | - | Atlético FC | 0:1 | |
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| 11. Jornada | 13.03.2021 | Barranquilla FC | - | Tigres FC | 1:0 | ||||
| 12. Jornada | 21.03.2021 | Valledupar FC | - | Barranquilla FC | 2:0 | ||||
| 13. Jornada | 27.03.2021 | Barranquilla FC | - | Llaneros FC | 1:0 | ||||
| 14. Jornada | 03.04.2021 | Unión Magdalena | - | Barranquilla FC | 4:1 | |
Colombia