| 1. Jornada | 13.07.2022 | Boyacá Chicó | - | Barranquilla FC | 1:0 | ||||
| 2. Jornada | 17.07.2022 | Barranquilla FC | - | Tigres FC | 3:0 |  |
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| 3. Jornada | 24.07.2022 | Cúcuta Deportivo | - | Barranquilla FC | 0:1 | ||||
| 4. Jornada | 30.07.2022 | Llaneros FC | - | Barranquilla FC | 1:1 | |
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| 5. Jornada | 04.08.2022 | Barranquilla FC | - | Boca Juniors de Cali | 1:1 | |
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| 6. Jornada | 09.08.2022 | Barranquilla FC | - | Leones FC | 3:1 | ||||
| 7. Jornada | 13.08.2022 | Bogotá FC | - | Barranquilla FC | 1:0 | ||||
| 8. Jornada | 21.08.2022 | Barranquilla FC | - | Deportes Quindío | 1:1 | |
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| 9. Jornada | 31.08.2022 | Real Cartagena | - | Barranquilla FC | 2:2 | ||||
| 10. Jornada | 04.09.2022 | Barranquilla FC | - | Atlético Huila | 2:1 | |
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| 12. Jornada | 14.09.2022 | Barranquilla FC | - | Real Santander | 2:1 | |
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| 13. Jornada | 20.09.2022 | Atlético FC | - | Barranquilla FC | 3:2 | ||||
| 14. Jornada | 25.09.2022 | Barranquilla FC | - | Real Cartagena | 2:3 |  |
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| 15. Jornada | 01.10.2022 | Valledupar FC | - | Barranquilla FC | 0:1 | ||||
| 16. Jornada | 08.10.2022 | Barranquilla FC | - | Orsomarso SC | 2:0 |
Colombia