| 1. Jornada | 13.08.2021 | Gudja United | - | Sirens FC | 0:1 | ||||
| 2. Jornada | 22.08.2021 | Hibernians FC | - | Gudja United | 2:1 | ||||
| 3. Jornada | 12.09.2021 | Gudja United | - | St. Luċija FC | 2:2 | ||||
| 4. Jornada | 19.09.2021 | Sliema Wanderers | - | Gudja United | 2:3 | ||||
| 5. Jornada | 25.09.2021 | Gudja United | - | Valletta FC | 2:0 | ||||
| 6. Jornada | 16.10.2021 | Birkirkara FC | - | Gudja United | 2:0 |  |
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| 7. Jornada | 23.10.2021 | Gudja United | - | Hamrun Spartans | 1:3 | ||||
| 8. Jornada | 31.10.2021 | Balzan FC | - | Gudja United | 1:0 |  |
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| 10. Jornada | 28.11.2021 | Gżira United | - | Gudja United | 3:2 | ||||
| 14. Jornada | 19.01.2022 | St. Luċija FC | - | Gudja United | 0:3 | ||||
| 15. Jornada | 22.01.2022 | Gudja United | - | Sliema Wanderers | 1:0 | |
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| 16. Jornada | 30.01.2022 | Valletta FC | - | Gudja United | 1:3 | ||||
| 17. Jornada | 06.02.2022 | Gudja United | - | Birkirkara FC | 0:1 | ||||
| 18. Jornada | 13.02.2022 | Hamrun Spartans | - | Gudja United | 0:1 |
Malta