| 1. Jornada | 24.07.2021 | FC Hradec Králové | - | Bohemians Praha 1905 | 1:1 | ||||
| 2. Jornada | 01.08.2021 | Bohemians Praha 1905 | - | Viktoria Plzeň | 1:2 | ||||
| 3. Jornada | 08.08.2021 | FK Jablonec | - | Bohemians Praha 1905 | 2:2 | ||||
| 5. Jornada | 21.08.2021 | FK Pardubice | - | Bohemians Praha 1905 | 3:0 | ||||
| 9. Jornada | 25.09.2021 | Baník Ostrava | - | Bohemians Praha 1905 | 4:1 |  |
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| 10. Jornada | 02.10.2021 | Bohemians Praha 1905 | - | Sigma Olomouc | 2:0 | ||||
| 11. Jornada | 16.10.2021 | FK Mladá Boleslav | - | Bohemians Praha 1905 | 4:1 | ||||
| 12. Jornada | 23.10.2021 | 1. FC Slovácko | - | Bohemians Praha 1905 | 1:0 | |
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| 14. Jornada | 06.11.2021 | Slovan Liberec | - | Bohemians Praha 1905 | 2:1 | |
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| 15. Jornada | 20.11.2021 | Bohemians Praha 1905 | - | Dynamo České Budějovice | 3:1 | ||||
| 16. Jornada | 27.11.2021 | Viktoria Plzeň | - | Bohemians Praha 1905 | 6:0 | ||||
| 23. Jornada | 26.02.2022 | Bohemians Praha 1905 | - | Baník Ostrava | 0:2 | |
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| 26. Jornada | 19.03.2022 | Bohemians Praha 1905 | - | 1. FC Slovácko | 1:2 |
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