| 1. Jornada | 08.01.2022 | Cruz Azul [Sub 20] | - | Club Tijuana [Sub 20] | 0:1 |  |
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| 2. Jornada | 16.01.2022 | Club Tijuana [Sub 20] | - | Club León [Sub 20] | 1:2 | ||||
| 4. Jornada | 06.02.2022 | Club Tijuana [Sub 20] | - | Pumas UNAM [Sub 20] | 1:1 | ||||
| 11. Jornada | 18.03.2022 | Club Tijuana [Sub 20] | - | FC Juárez [Sub 20] | 1:1 | ||||
| 12. Jornada | 03.04.2022 | UANL Tigres [Sub 20] | - | Club Tijuana [Sub 20] | 1:2 | |
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| 9. Jornada | 06.04.2022 | Club Tijuana [Sub 20] | - | Atlético San Luis [Sub 20] | 2:1 | ||||
| 13. Jornada | 11.04.2022 | CF Pachuca [Sub 20] | - | Club Tijuana [Sub 20] | 0:0 | ||||
| 14. Jornada | 16.04.2022 | Club Tijuana [Sub 20] | - | CF América [Sub 20] | 4:0 | |
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| 15. Jornada | 19.04.2022 | Deportivo Guadalajara [Sub 20] | - | Club Tijuana [Sub 20] | 1:1 | ||||
| 16. Jornada | 25.04.2022 | Club Tijuana [Sub 20] | - | Gallos Blancos [Sub 20] | 1:0 | ||||
| 17. Jornada | 30.04.2022 | CF Monterrey [Sub 20] | - | Club Tijuana [Sub 20] | 3:0 |
México