| 4. Jornada | 15.05.2022 | Chicago Fire | - | FC Cincinnati | 1:2 | ||||
| 4. Jornada | 19.05.2022 | New York RB | - | Chicago Fire | 3:3 | ||||
| 4. Jornada | 22.05.2022 | New York City FC | - | Chicago Fire | 1:0 | ||||
| 4. Jornada | 29.05.2022 | Toronto FC | - | Chicago Fire | 3:2 | ||||
| 6. Jornada | 04.07.2022 | San Jose Earthquakes | - | Chicago Fire | 2:1 | ||||
| 6. Jornada | 10.07.2022 | Chicago Fire | - | Columbus Crew | 2:3 | ||||
| 6. Jornada | 14.07.2022 | Chicago Fire | - | Toronto FC | 2:0 | ||||
| 6. Jornada | 17.07.2022 | Chicago Fire | - | Seattle Sounders | 1:0 | ||||
| 6. Jornada | 24.07.2022 | Vancouver Whitecaps | - | Chicago Fire | 1:3 | ||||
| 6. Jornada | 30.07.2022 | Chicago Fire | - | Atlanta United FC | 0:0 | ||||
| 7. Jornada | 07.08.2022 | Charlotte FC | - | Chicago Fire | 2:3 | ||||
| 7. Jornada | 14.08.2022 | Philadelphia Union | - | Chicago Fire | 4:1 | ||||
| 7. Jornada | 22.08.2022 | Chicago Fire | - | New York City FC | 0:2 | ||||
| 7. Jornada | 28.08.2022 | Chicago Fire | - | CF Montréal | 0:2 |  |
México