| 5. Jornada | 05.08.2021 | Philadelphia Union | - | Toronto FC | 3:0 | ||||
| 5. Jornada | 08.08.2021 | Toronto FC | - | New York City FC | 2:2 | ||||
| 5. Jornada | 15.08.2021 | Toronto FC | - | New England Revolution | 1:2 | ||||
| 5. Jornada | 19.08.2021 | Atlanta United FC | - | Toronto FC | 1:0 | ||||
| 5. Jornada | 22.08.2021 | Inter Miami CF | - | Toronto FC | 3:1 | ||||
| 5. Jornada | 28.08.2021 | CF Montréal | - | Toronto FC | 3:1 |  |
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| 6. Jornada | 12.09.2021 | FC Cincinnati | - | Toronto FC | 2:0 | ||||
| 6. Jornada | 15.09.2021 | Toronto FC | - | Inter Miami CF | 0:1 | ||||
| 6. Jornada | 19.09.2021 | Toronto FC | - | Nashville SC | 2:1 | ||||
| 6. Jornada | 26.09.2021 | Colorado Rapids | - | Toronto FC | 0:0 | ||||
| 6. Jornada | 30.09.2021 | Toronto FC | - | FC Cincinnati | 3:2 | |
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| 7. Jornada | 03.10.2021 | Toronto FC | - | Chicago Fire | 3:1 | ||||
| 7. Jornada | 17.10.2021 | Toronto FC | - | Atlanta United FC | 0:2 | |
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| 8. Jornada | 07.11.2021 | Toronto FC | - | D.C. United | 1:3 |
Nigeria