| 2. Jornada | 18.09.2021 | Cerrito | - | Cerro Largo | 1:1 | ||||
| 3. Jornada | 26.09.2021 | Progreso | - | Cerrito | 0:1 |  |
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| 4. Jornada | 02.10.2021 | Cerrito | - | Sud América | 2:0 | ||||
| 5. Jornada | 11.10.2021 | Plaza Colonia | - | Cerrito | 3:3 | |
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| 6. Jornada | 17.10.2021 | Cerrito | - | Fénix | 2:4 |  |
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| 7. Jornada | 21.10.2021 | Boston River | - | Cerrito | 3:2 | |
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| 8. Jornada | 24.10.2021 | Cerrito | - | Montevideo Wanderers | 2:2 | ||||
| 9. Jornada | 29.10.2021 | Rentistas | - | Cerrito | 1:2 | ||||
| 10. Jornada | 05.11.2021 | Cerrito | - | Peñarol | 1:3 | ||||
| 11. Jornada | 07.11.2021 | Cerrito | - | Montevideo City Torque | 0:2 | |
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| 12. Jornada | 13.11.2021 | Cerrito | - | Villa Española | 1:0 | ||||
| 13. Jornada | 19.11.2021 | Nacional | - | Cerrito | 1:0 | |
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| 15. Jornada | 06.12.2021 | Cerrito | - | Liverpool | 2:1 |
Uruguay
Chile