| 1. Jornada | 18.01.2021 | Plaza Colonia | - | Liverpool | 0:0 | ||||
| 2. Jornada | 21.01.2021 | Deportivo Maldonado | - | Liverpool | 2:4 |  |
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| 3. Jornada | 30.01.2021 | Progreso | - | Liverpool | 0:4 | |
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| 4. Jornada | 03.02.2021 | Liverpool | - | Rentistas | 2:2 | |
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| 5. Jornada | 06.02.2021 | Fénix | - | Liverpool | 0:2 | |
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| 6. Jornada | 10.02.2021 | Liverpool | - | Cerro Largo | 3:2 | |
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| 7. Jornada | 14.02.2021 | CA Cerro | - | Liverpool | 1:1 | ||||
| 8. Jornada | 17.02.2021 | Liverpool | - | Montevideo Wanderers | 2:1 | |
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| 9. Jornada | 20.02.2021 | Defensor Sporting | - | Liverpool | 0:3 | |
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| 10. Jornada | 26.02.2021 | Liverpool | - | Peñarol | 1:1 | |
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| 11. Jornada | 07.03.2021 | Danubio | - | Liverpool | 0:1 | |
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| 12. Jornada | 14.03.2021 | Liverpool | - | River Plate | 3:2 | ||||
| 13. Jornada | 22.03.2021 | Nacional | - | Liverpool | 0:4 | |
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| 14. Jornada | 24.03.2021 | Liverpool | - | Montevideo City Torque | 4:1 | |
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