| 1. Jornada | 11.09.2021 | Fortuna Köln [Juvenil] | - | Bayer Leverkusen [Juvenil] | 0:2 | ||||
| 2. Jornada | 18.09.2021 | Bayer Leverkusen [Juvenil] | - | MSV Duisburg [Juvenil] | 2:2 |  |
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| 3. Jornada | 25.09.2021 | Arminia Bielefeld [Juvenil] | - | Bayer Leverkusen [Juvenil] | 0:4 | ||||
| 4. Jornada | 02.10.2021 | Bayer Leverkusen [Juvenil] | - | Schalke [Juvenil] | 2:2 | ||||
| 6. Jornada | 23.10.2021 | Bayer Leverkusen [Juvenil] | - | Fortuna Düsseldorf [Juvenil] | 3:1 |  |
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| 5. Jornada | 20.11.2021 | Colonia [Juvenil] | - | Bayer Leverkusen [Juvenil] | 1:1 | |
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| 9. Jornada | 05.12.2021 | Bayer Leverkusen [Juvenil] | - | Wuppertaler SV [Juvenil] | 7:0 | ||||
| 10. Jornada | 04.02.2022 | Borussia Dortmund [Juvenil] | - | Bayer Leverkusen [Juvenil] | 3:1 | ||||
| 12. Jornada | 20.02.2022 | Bor. Mönchengladbach [Juvenil] | - | Bayer Leverkusen [Juvenil] | 0:1 | ||||
| 13. Jornada | 05.03.2022 | Bayer Leverkusen [Juvenil] | - | VfL Bochum [Juvenil] | 0:0 | ||||
| 14. Jornada | 13.04.2022 | Preußen Münster [Juvenil] | - | Bayer Leverkusen [Juvenil] | 0:1 | |
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| 16. Jornada | 23.04.2022 | Rot-Weiß Oberhausen [Juvenil] | - | Bayer Leverkusen [Juvenil] | 3:1 | |
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