| 2. Jornada | 23.05.2021 | Plaza Colonia | - | Montevideo City Torque | 1:0 | ||||
| 3. Jornada | 29.05.2021 | Villa Española | - | Plaza Colonia | 1:3 | ||||
| 4. Jornada | 05.06.2021 | Plaza Colonia | - | Nacional | 1:2 | ||||
| 8. Jornada | 28.06.2021 | Plaza Colonia | - | Cerro Largo | 1:1 |  |
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| 9. Jornada | 05.07.2021 | Progreso | - | Plaza Colonia | 1:2 | ||||
| 11. Jornada | 17.07.2021 | Deportivo Maldonado | - | Plaza Colonia | 0:1 | ||||
| 12. Jornada | 01.08.2021 | Fénix | - | Plaza Colonia | 0:1 | ||||
| 13. Jornada | 09.08.2021 | Plaza Colonia | - | Boston River | 0:0 | ||||
| 14. Jornada | 16.08.2021 | Montevideo Wanderers | - | Plaza Colonia | 0:2 | |
Argentina