| 1. Jornada | 25.07.2021 | MFK Zemplín Michalovce | - | FC DAC 1904 | 4:1 | ||||
| 3. Jornada | 08.08.2021 | ŠKF Sereď | - | FC DAC 1904 | 1:0 | ||||
| 4. Jornada | 14.08.2021 | FK Senica | - | FC DAC 1904 | 1:1 | ||||
| 5. Jornada | 22.08.2021 | FC DAC 1904 | - | AS Trenčín | 1:1 | ||||
| 6. Jornada | 27.08.2021 | FK Pohronie | - | FC DAC 1904 | 0:3 | ||||
| 13. Jornada | 30.10.2021 | Tatran Liptovský Mikuláš | - | FC DAC 1904 | 1:0 | ||||
| 14. Jornada | 06.11.2021 | FC DAC 1904 | - | ŠKF Sereď | 1:3 | ||||
| 16. Jornada | 27.11.2021 | AS Trenčín | - | FC DAC 1904 | 0:1 |  |
Moldavia
Rumania