| 2. Jornada | 01.05.2021 | CF Montréal | - | Columbus Crew | 0:0 | ||||
| 2. Jornada | 13.05.2021 | Toronto FC | - | Columbus Crew | 2:0 | ||||
| 4. Jornada | 10.07.2021 | FC Cincinnati | - | Columbus Crew | 2:2 | ||||
| 4. Jornada | 18.07.2021 | Columbus Crew | - | New York City FC | 2:1 | ||||
| 6. Jornada | 05.09.2021 | Orlando City | - | Columbus Crew | 3:2 | ||||
| 6. Jornada | 19.09.2021 | New England Revolution | - | Columbus Crew | 1:1 |  |
Estados Unidos
Italia