| 4. Jornada | 14.08.2021 | Cruz Azul [Sub 20] | - | Deportivo Toluca [Sub 20] | 2:2 | ||||
| 5. Jornada | 17.08.2021 | Deportivo Toluca [Sub 20] | - | Mazatlán FC [Sub 20] | 3:1 |  |
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| 8. Jornada | 13.09.2021 | CF Pachuca [Sub 20] | - | Deportivo Toluca [Sub 20] | 2:0 | ||||
| 9. Jornada | 18.09.2021 | Deportivo Toluca [Sub 20] | - | CF América [Sub 20] | 3:1 | ||||
| 11. Jornada | 22.09.2021 | CF Monterrey [Sub 20] | - | Deportivo Toluca [Sub 20] | 1:0 | ||||
| 10. Jornada | 26.09.2021 | Deportivo Toluca [Sub 20] | - | Atlético San Luis [Sub 20] | 2:0 |
México