| 1. Jornada | 07.08.2021 | Lyon | - | Stade Brestois 29 | 1:1 |  |
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| 2. Jornada | 15.08.2021 | Angers | - | Lyon | 3:0 | ||||
| 4. Jornada | 27.08.2021 | Nantes | - | Lyon | 0:1 | ||||
| 6. Jornada | 19.09.2021 | París Saint-Germain | - | Lyon | 2:1 | ||||
| 7. Jornada | 22.09.2021 | Lyon | - | Troyes | 3:1 | ||||
| 8. Jornada | 25.09.2021 | Lyon | - | Lorient | 1:1 | ||||
| 12. Jornada | 30.10.2021 | Lyon | - | RC Lens | 2:1 | ||||
| 13. Jornada | 07.11.2021 | Rennes | - | Lyon | 4:1 | |
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| 15. Jornada | 28.11.2021 | Montpellier | - | Lyon | 0:1 | |
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| 16. Jornada | 01.12.2021 | Lyon | - | Stade de Reims | 1:2 | ||||
| 18. Jornada | 12.12.2021 | Lille | - | Lyon | 0:0 | ||||
| 19. Jornada | 22.12.2021 | Lyon | - | FC Metz | 1:1 |
Argelia
