| 1. Jornada | 06.02.2022 | The Strongest | - | Oriente Petrolero | 2:0 |  |
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| 2. Jornada | 13.02.2022 | Atlético Palmaflor | - | The Strongest | 0:3 | ||||
| 5. Jornada | 05.03.2022 | The Strongest | - | Nacional Potosí | 1:1 | ||||
| 6. Jornada | 15.03.2022 | The Strongest | - | Bolívar | 0:1 | ||||
| 11. Jornada | 24.04.2022 | Universitario de Sucre | - | The Strongest | 0:1 | |
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| 12. Jornada | 30.04.2022 | The Strongest | - | Real Santa Cruz | 1:1 | |
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| 15. Jornada | 14.05.2022 | The Strongest | - | CD Guabirá | 0:0 | |
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| 16. Jornada | 21.05.2022 | The Strongest | - | Club Aurora | 1:0 |
Paraguay