| 1. Jornada | 24.07.2021 | Sparta Praga | - | Sigma Olomouc | 3:2 | ||||
| 4. Jornada | 14.08.2021 | Sigma Olomouc | - | Dynamo České Budějovice | 3:3 | ||||
| 8. Jornada | 17.09.2021 | Sigma Olomouc | - | Baník Ostrava | 1:1 | ||||
| 9. Jornada | 26.09.2021 | FK Teplice | - | Sigma Olomouc | 0:0 | ||||
| 10. Jornada | 02.10.2021 | Bohemians Praha 1905 | - | Sigma Olomouc | 2:0 | ||||
| 11. Jornada | 17.10.2021 | Sigma Olomouc | - | MFK Karviná | 2:0 | ||||
| 12. Jornada | 23.10.2021 | Slovan Liberec | - | Sigma Olomouc | 2:0 | ||||
| 3. Jornada | 27.10.2021 | Slavia Praga | - | Sigma Olomouc | 1:0 | ||||
| 13. Jornada | 30.10.2021 | Sigma Olomouc | - | 1. FC Slovácko | 0:3 | ||||
| 14. Jornada | 06.11.2021 | Viktoria Plzeň | - | Sigma Olomouc | 0:0 | ||||
| 15. Jornada | 20.11.2021 | Sigma Olomouc | - | FC Hradec Králové | 2:2 | ||||
| 17. Jornada | 04.12.2021 | Sigma Olomouc | - | Slavia Praga | 0:1 | ||||
| 30. Jornada | 20.04.2022 | Sigma Olomouc | - | Sparta Praga | 2:0 |
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