| 3. Jornada | 06.08.2021 | Club Tijuana [Sub 18] | - | Deportivo Toluca [Sub 18] | 3:0 | ||||
| 4. Jornada | 13.08.2021 | FC Juárez [Sub 18] | - | Club Tijuana [Sub 18] | 3:2 |  |
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| 5. Jornada | 17.08.2021 | Club Tijuana [Sub 18] | - | Puebla FC [Sub 18] | 5:2 | ||||
| 6. Jornada | 22.08.2021 | CF América [Sub 18] | - | Club Tijuana [Sub 18] | 4:0 | ||||
| 7. Jornada | 27.08.2021 | Club Tijuana [Sub 18] | - | CF Monterrey [Sub 18] | 0:0 | ||||
| 8. Jornada | 10.09.2021 | Club Tijuana [Sub 18] | - | Santos Laguna [Sub 18] | 3:0 | ||||
| 12. Jornada | 03.10.2021 | Club Tijuana [Sub 18] | - | Cruz Azul [Sub 18] | 3:2 | ||||
| 13. Jornada | 14.10.2021 | Gallos Blancos [Sub 18] | - | Club Tijuana [Sub 18] | 2:0 | ||||
| 15. Jornada | 24.10.2021 | Pumas UNAM [Sub 18] | - | Club Tijuana [Sub 18] | 2:2 | ||||
| 16. Jornada | 28.10.2021 | Atlas Guadalajara [Sub 18] | - | Club Tijuana [Sub 18] | 1:0 | ||||
| 17. Jornada | 10.11.2021 | Club Tijuana [Sub 18] | - | CF Pachuca [Sub 18] | 2:2 |
México