| 6. Jornada | 22.08.2021 | CF América [Sub 18] | - | Club Tijuana [Sub 18] | 4:0 | ||||
| 10. Jornada | 24.09.2021 | Club Tijuana [Sub 18] | - | Mazatlán FC [Sub 18] | 1:2 |  |
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| 12. Jornada | 03.10.2021 | Club Tijuana [Sub 18] | - | Cruz Azul [Sub 18] | 3:2 | |
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| 13. Jornada | 14.10.2021 | Gallos Blancos [Sub 18] | - | Club Tijuana [Sub 18] | 2:0 | ||||
| 14. Jornada | 20.10.2021 | Club Tijuana [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 1:3 | ||||
| 15. Jornada | 24.10.2021 | Pumas UNAM [Sub 18] | - | Club Tijuana [Sub 18] | 2:2 | ||||
| 16. Jornada | 28.10.2021 | Atlas Guadalajara [Sub 18] | - | Club Tijuana [Sub 18] | 1:0 | ||||
| 17. Jornada | 10.11.2021 | Club Tijuana [Sub 18] | - | CF Pachuca [Sub 18] | 2:2 |
México