| 1. Jornada | 25.07.2010 | Club San Luis | - | CF Monterrey | 1:1 | ||||
| 2. Jornada | 01.08.2010 | Puebla FC | - | Club San Luis | 2:1 | ||||
| 3. Jornada | 08.08.2010 | Club San Luis | - | Deportivo Guadalajara | 0:1 | ||||
| 4. Jornada | 15.08.2010 | Club San Luis | - | Monarcas Morelia | 1:0 | ||||
| 5. Jornada | 21.08.2010 | Estudiantes Tecos | - | Club San Luis | 3:2 | ||||
| 6. Jornada | 29.08.2010 | Club San Luis | - | Atlante | 2:1 | ||||
| 7. Jornada | 12.09.2010 | Pumas UNAM | - | Club San Luis | 0:1 | ||||
| 8. Jornada | 19.09.2010 | Club San Luis | - | CF Pachuca | 1:0 | ||||
| 9. Jornada | 26.09.2010 | Jaguares Chiapas | - | Club San Luis | 2:1 | ||||
| 10. Jornada | 03.10.2010 | Club San Luis | - | UANL Tigres | 1:0 | ||||
| 11. Jornada | 10.10.2010 | Atlas Guadalajara | - | Club San Luis | 2:1 |  |
|||
| 12. Jornada | 17.10.2010 | Club San Luis | - | Gallos Blancos (old) | 3:2 | ||||
| 13. Jornada | 23.10.2010 | Club Necaxa | - | Club San Luis | 0:2 | ||||
| 14. Jornada | 29.10.2010 | Club San Luis | - | CF América | 1:2 | ||||
| 15. Jornada | 31.10.2010 | Deportivo Toluca | - | Club San Luis | 1:2 | ||||
| 16. Jornada | 07.11.2010 | Club San Luis | - | Santos Laguna | 1:1 | ||||
| 17. Jornada | 14.11.2010 | Cruz Azul | - | Club San Luis | 1:0 |
México