| 1. Jornada | 09.01.2011 | CF Monterrey | - | Club San Luis | 0:2 |  |
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| 2. Jornada | 16.01.2011 | Club San Luis | - | Puebla FC | 3:0 | |
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| 3. Jornada | 23.01.2011 | Deportivo Guadalajara | - | Club San Luis | 1:1 | ||||
| 4. Jornada | 30.01.2011 | Monarcas Morelia | - | Club San Luis | 3:3 | ||||
| 14. Jornada | 03.02.2011 | CF América | - | Club San Luis | 3:0 | |
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| 5. Jornada | 06.02.2011 | Club San Luis | - | Estudiantes Tecos | 3:2 | ||||
| 6. Jornada | 13.02.2011 | Atlante | - | Club San Luis | 0:0 | ||||
| 7. Jornada | 19.02.2011 | Club San Luis | - | Pumas UNAM | 0:1 | ||||
| 8. Jornada | 27.02.2011 | CF Pachuca | - | Club San Luis | 0:0 | ||||
| 9. Jornada | 06.03.2011 | Club San Luis | - | Jaguares Chiapas | 0:0 | ||||
| 10. Jornada | 13.03.2011 | UANL Tigres | - | Club San Luis | 1:1 | |
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| 11. Jornada | 20.03.2011 | Club San Luis | - | Atlas Guadalajara | 1:1 | ||||
| 12. Jornada | 03.04.2011 | Gallos Blancos (old) | - | Club San Luis | 3:2 | |
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| 13. Jornada | 10.04.2011 | Club San Luis | - | Club Necaxa | 0:0 | ||||
| 15. Jornada | 17.04.2011 | Club San Luis | - | Deportivo Toluca | 1:2 | ||||
| 16. Jornada | 24.04.2011 | Santos Laguna | - | Club San Luis | 1:3 | ||||
| 17. Jornada | 01.05.2011 | Club San Luis | - | Cruz Azul | 0:0 |
México