| 1. Jornada | 10.01.2021 | UANL Tigres | - | Club León | 2:0 | ||||
| 2. Jornada | 19.01.2021 | Club León | - | CF Pachuca | 0:0 | ||||
| 4. Jornada | 02.02.2021 | Club León | - | Atlético San Luis | 3:1 |  |
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| 5. Jornada | 09.02.2021 | Club León | - | Deportivo Guadalajara | 1:3 | |
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| 6. Jornada | 13.02.2021 | Club Tijuana | - | Club León | 2:0 | ||||
| 7. Jornada | 21.02.2021 | Pumas UNAM | - | Club León | 0:1 | |
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| 8. Jornada | 28.02.2021 | Club León | - | Cruz Azul | 0:1 | ||||
| 9. Jornada | 03.03.2021 | Club León | - | Puebla FC | 1:2 | ||||
| 10. Jornada | 07.03.2021 | CF América | - | Club León | 2:1 | ||||
| 3. Jornada | 11.03.2021 | CF Monterrey | - | Club León | 1:1 | ||||
| 11. Jornada | 16.03.2021 | Club León | - | Club Necaxa | 3:1 | |
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| 12. Jornada | 22.03.2021 | Santos Laguna | - | Club León | 1:2 | ||||
| 13. Jornada | 05.04.2021 | Club León | - | Deportivo Toluca | 2:1 |  |
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| 14. Jornada | 11.04.2021 | Atlas Guadalajara | - | Club León | 1:3 | ||||
| 15. Jornada | 20.04.2021 | Club León | - | FC Juárez | 2:0 | ||||
| 17. Jornada | 02.05.2021 | Club León | - | Gallos Blancos | 2:1 |
Colombia