| 4. Jornada | 07.05.2022 | CF Montréal | - | Orlando City | 4:1 | ||||
| 4. Jornada | 14.05.2022 | Toronto FC | - | Orlando City | 0:1 | ||||
| 4. Jornada | 23.05.2022 | Austin FC | - | Orlando City | 2:2 | ||||
| 4. Jornada | 29.05.2022 | Orlando City | - | FC Dallas | 1:3 | ||||
| 5. Jornada | 16.06.2022 | New England Revolution | - | Orlando City | 1:1 |  |
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| 5. Jornada | 19.06.2022 | Orlando City | - | Houston Dynamo | 2:1 | ||||
| 5. Jornada | 25.06.2022 | FC Cincinnati | - | Orlando City | 1:0 | ||||
| 6. Jornada | 05.07.2022 | Orlando City | - | D.C. United | 3:5 | ||||
| 6. Jornada | 10.07.2022 | Orlando City | - | Inter Miami CF | 1:0 | ||||
| 6. Jornada | 17.07.2022 | Atlanta United FC | - | Orlando City | 1:1 | ||||
| 6. Jornada | 24.07.2022 | Orlando City | - | Philadelphia Union | 0:1 | ||||
| 7. Jornada | 14.08.2022 | New York RB | - | Orlando City | 0:1 | ||||
| 7. Jornada | 22.08.2022 | Charlotte FC | - | Orlando City | 1:2 | |
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| 7. Jornada | 29.08.2022 | Orlando City | - | New York City FC | 2:1 | ||||
| 8. Jornada | 11.09.2022 | Philadelphia Union | - | Orlando City | 5:1 | ||||
| 8. Jornada | 15.09.2022 | Orlando City | - | Atlanta United FC | 0:1 | ||||
| 9. Jornada | 02.10.2022 | New York City FC | - | Orlando City | 2:1 |
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