| 3. Jornada | 07.08.2021 | FC Fastav Zlín | - | FK Teplice | 3:0 | ||||
| 4. Jornada | 14.08.2021 | MFK Karviná | - | FC Fastav Zlín | 2:3 | ||||
| 5. Jornada | 21.08.2021 | FC Fastav Zlín | - | Sigma Olomouc | 1:4 | ||||
| 18. Jornada | 11.12.2021 | FC Fastav Zlín | - | MFK Karviná | 2:1 |  |
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| 19. Jornada | 19.12.2021 | Sigma Olomouc | - | FC Fastav Zlín | 1:1 | ||||
| 21. Jornada | 12.02.2022 | Bohemians Praha 1905 | - | FC Fastav Zlín | 1:0 | ||||
| 20. Jornada | 15.02.2022 | FC Fastav Zlín | - | Slovan Liberec | 2:0 | ||||
| 22. Jornada | 19.02.2022 | FC Fastav Zlín | - | 1. FC Slovácko | 1:0 | ||||
| 24. Jornada | 05.03.2022 | FC Fastav Zlín | - | Viktoria Plzeň | 1:2 | ||||
| 27. Jornada | 02.04.2022 | Dynamo České Budějovice | - | FC Fastav Zlín | 2:2 | ||||
| 28. Jornada | 10.04.2022 | FK Jablonec | - | FC Fastav Zlín | 1:1 | ||||
| 30. Jornada | 20.04.2022 | Slavia Praga | - | FC Fastav Zlín | 3:0 |
República Checa