| 1. Jornada | 25.07.2021 | Dynamo České Budějovice | - | FK Teplice | 1:0 | ||||
| 2. Jornada | 30.07.2021 | FK Teplice | - | Slavia Praga | 1:3 | ||||
| 3. Jornada | 07.08.2021 | FC Fastav Zlín | - | FK Teplice | 3:0 | ||||
| 4. Jornada | 15.08.2021 | FK Teplice | - | FK Jablonec | 1:0 | ||||
| 5. Jornada | 21.08.2021 | FK Mladá Boleslav | - | FK Teplice | 3:1 |  |
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| 6. Jornada | 29.08.2021 | Bohemians Praha 1905 | - | FK Teplice | 4:2 | |
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| 12. Jornada | 24.10.2021 | FC Hradec Králové | - | FK Teplice | 3:0 | |
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| 14. Jornada | 07.11.2021 | Sparta Praga | - | FK Teplice | 4:2 | |
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| 15. Jornada | 21.11.2021 | FK Teplice | - | FK Pardubice | 1:2 | |
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| 16. Jornada | 28.11.2021 | Slavia Praga | - | FK Teplice | 3:0 | ||||
| 17. Jornada | 04.12.2021 | FK Teplice | - | FC Fastav Zlín | 4:1 | |
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| 18. Jornada | 12.12.2021 | FK Jablonec | - | FK Teplice | 0:2 | ||||
| 19. Jornada | 19.12.2021 | FK Teplice | - | FK Mladá Boleslav | 0:1 | ||||
| 20. Jornada | 05.02.2022 | FK Teplice | - | Bohemians Praha 1905 | 1:0 | ||||
| 21. Jornada | 12.02.2022 | Baník Ostrava | - | FK Teplice | 2:4 | ||||
| 22. Jornada | 20.02.2022 | FK Teplice | - | MFK Karviná | 1:0 | ||||
| 24. Jornada | 06.03.2022 | FK Teplice | - | 1. FC Slovácko | 0:1 | ||||
| 25. Jornada | 12.03.2022 | Viktoria Plzeň | - | FK Teplice | 1:0 | |
República Checa