| 6. Jornada | 13.03.2022 | Talleres de Córdoba | - | San Lorenzo | 0:1 | ||||
| 8. Jornada | 03.04.2022 | San Lorenzo | - | Atlético Tucumán | 1:1 |  |
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| 9. Jornada | 09.04.2022 | Sarmiento de Junín | - | San Lorenzo | 2:1 | ||||
| 10. Jornada | 16.04.2022 | San Lorenzo | - | Platense | 2:2 | ||||
| 11. Jornada | 19.04.2022 | Unión de Santa Fe | - | San Lorenzo | 1:2 | ||||
| 12. Jornada | 23.04.2022 | San Lorenzo | - | Patronato de Paraná | 1:2 | ||||
| 13. Jornada | 28.04.2022 | Newell's Old Boys | - | San Lorenzo | 1:2 | ||||
| 14. Jornada | 06.05.2022 | San Lorenzo | - | Racing Club | 1:1 |
Argentina