| 1. Jornada | 25.07.2021 | Slovan Liberec | - | 1. FC Slovácko | 0:1 | ||||
| 6. Jornada | 28.08.2021 | 1. FC Slovácko | - | FK Pardubice | 2:1 | ||||
| 7. Jornada | 12.09.2021 | Slavia Praga | - | 1. FC Slovácko | 2:1 | ||||
| 8. Jornada | 18.09.2021 | 1. FC Slovácko | - | FC Fastav Zlín | 3:0 | ||||
| 9. Jornada | 26.09.2021 | FK Mladá Boleslav | - | 1. FC Slovácko | 3:5 | ||||
| 10. Jornada | 02.10.2021 | 1. FC Slovácko | - | FK Teplice | 3:2 |  |
|||
| 11. Jornada | 16.10.2021 | Baník Ostrava | - | 1. FC Slovácko | 1:2 | ||||
| 12. Jornada | 23.10.2021 | 1. FC Slovácko | - | Bohemians Praha 1905 | 1:0 | ||||
| 13. Jornada | 30.10.2021 | Sigma Olomouc | - | 1. FC Slovácko | 0:3 | ||||
| 14. Jornada | 07.11.2021 | MFK Karviná | - | 1. FC Slovácko | 2:2 | ||||
| 15. Jornada | 21.11.2021 | 1. FC Slovácko | - | Sparta Praga | 4:0 | ||||
| 16. Jornada | 27.11.2021 | Dynamo České Budějovice | - | 1. FC Slovácko | 3:2 | ||||
| 17. Jornada | 05.12.2021 | 1. FC Slovácko | - | Viktoria Plzeň | 1:2 | ||||
| 18. Jornada | 11.12.2021 | FC Hradec Králové | - | 1. FC Slovácko | 2:2 | ||||
| 19. Jornada | 18.12.2021 | 1. FC Slovácko | - | FK Jablonec | 2:1 | |
República Checa