| 1. Jornada | 16.01.2022 | Sololá FC | - | Cobán Imperial | 0:0 |  |
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| 2. Jornada | 22.01.2022 | Cobán Imperial | - | Comunicaciones | 2:0 | ||||
| 3. Jornada | 30.01.2022 | Deportivo Malacateco | - | Cobán Imperial | 0:0 | |
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| 4. Jornada | 02.02.2022 | Cobán Imperial | - | Xelaju MC | 3:1 |  |
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| 6. Jornada | 10.02.2022 | Antigua GFC | - | Cobán Imperial | 0:1 | |
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| 8. Jornada | 19.02.2022 | CSD Municipal | - | Cobán Imperial | 3:2 | |
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| 12. Jornada | 12.03.2022 | Cobán Imperial | - | Sololá FC | 2:1 | |
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| 13. Jornada | 21.03.2022 | Comunicaciones | - | Cobán Imperial | 1:4 | ||||
| 16. Jornada | 09.04.2022 | Cobán Imperial | - | Nueva Concepción | 5:1 | |
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| 17. Jornada | 16.04.2022 | Cobán Imperial | - | Antigua GFC | 0:0 | |
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| 18. Jornada | 20.04.2022 | Iztapa | - | Cobán Imperial | 3:0 | ||||
| 21. Jornada | 04.05.2022 | Cobán Imperial | - | Santa Lucía | 1:0 | |
Brasil