| 2. Jornada | 24.07.2010 | 1. FC Tatran Prešov | - | FK Senica | 0:1 |  |
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| 4. Jornada | 07.08.2010 | FC DAC 1904 | - | FK Senica | 2:3 | |
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| 10. Jornada | 26.09.2010 | MFK Ružomberok | - | FK Senica | 1:2 | |
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| 15. Jornada | 06.11.2010 | FK Senica | - | FC DAC 1904 | 1:1 | |
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| 16. Jornada | 13.11.2010 | MFK Košice | - | FK Senica | 2:1 | |
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| 17. Jornada | 19.11.2010 | FK Senica | - | MŠK Žilina | 2:1 | |
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| 18. Jornada | 27.11.2010 | Slovan Bratislava | - | FK Senica | 2:2 | |
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| 19. Jornada | 26.02.2011 | FK Senica | - | FK Dukla Banská Bystrica | 3:0 | |
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| 29. Jornada | 04.05.2011 | FK Senica | - | Slovan Bratislava | 1:2 | |
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| 33. Jornada | 25.05.2011 | FK Senica | - | Zlaté Moravce | 2:0 | |
República Checa