| 2. Jornada | 15.01.2022 | Atlas Guadalajara [] | - | Club Tijuana [] | 1:2 | ||||
| 3. Jornada | 22.01.2022 | Club Tijuana [] | - | Atlético San Luis [] | 5:0 | ||||
| 4. Jornada | 29.01.2022 | UANL Tigres [] | - | Club Tijuana [] | 2:0 | ||||
| 12. Jornada | 26.03.2022 | Club Tijuana [] | - | UANL Tigres [] | 3:1 | ||||
| 13. Jornada | 02.04.2022 | Club Tijuana [] | - | Atlas Guadalajara [] | 0:1 | ||||
| 14. Jornada | 05.04.2022 | Atlético San Luis [] | - | Club Tijuana [] | 0:3 | ||||
| 15. Jornada | 20.04.2022 | Club Tijuana [] | - | Santos Laguna [] | 4:1 |  |
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| 16. Jornada | 23.04.2022 | Club León [] | - | Club Tijuana [] | 2:1 | ||||
| 18. Jornada | 07.05.2022 | CF Monterrey [] | - | Club Tijuana [] | 1:0 |
México