| 1. Jornada | 06.02.2022 | San Francisco FC | - | Veraguas United | 0:1 | ||||
| 2. Jornada | 12.02.2022 | San Francisco FC | - | Independiente de La Chorrera | 2:0 | ||||
| 5. Jornada | 05.03.2022 | Herrera FC | - | San Francisco FC | 0:0 | ||||
| 6. Jornada | 09.03.2022 | San Francisco FC | - | Árabe Unido | 0:0 | ||||
| 7. Jornada | 14.03.2022 | Alianza | - | San Francisco FC | 2:1 |  |
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| 8. Jornada | 21.03.2022 | Tauro FC | - | San Francisco FC | 1:0 |  |
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| 10. Jornada | 02.04.2022 | San Francisco FC | - | Plaza Amador | 2:2 | ||||
| 11. Jornada | 09.04.2022 | Potros del Este | - | San Francisco FC | 0:0 | ||||
| 13. Jornada | 24.04.2022 | Independiente de La Chorrera | - | San Francisco FC | 1:4 | |
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| 15. Jornada | 30.04.2022 | UD Universitario | - | San Francisco FC | 0:1 | ||||
| 12. Jornada | 05.05.2022 | Veraguas United | - | San Francisco FC | 0:2 | |
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| 16. Jornada | 08.05.2022 | San Francisco FC | - | Herrera FC | 3:1 | |
Panamá