| 1. Jornada | 25.07.2021 | Deportivo Guadalajara | - | Atlético San Luis | 1:2 | ||||
| 2. Jornada | 03.08.2021 | Atlético San Luis | - | Gallos Blancos | 1:1 | ||||
| 3. Jornada | 08.08.2021 | Pumas UNAM | - | Atlético San Luis | 1:3 | ||||
| 6. Jornada | 22.08.2021 | Atlético San Luis | - | Cruz Azul | 0:0 |  |
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| 7. Jornada | 28.08.2021 | Mazatlán FC | - | Atlético San Luis | 2:2 | ||||
| 8. Jornada | 11.09.2021 | Puebla FC | - | Atlético San Luis | 2:2 | ||||
| 9. Jornada | 17.09.2021 | Atlético San Luis | - | Club Tijuana | 4:1 | ||||
| 14. Jornada | 22.09.2021 | FC Juárez | - | Atlético San Luis | 1:0 | ||||
| 10. Jornada | 26.09.2021 | Deportivo Toluca | - | Atlético San Luis | 1:2 | ||||
| 11. Jornada | 30.09.2021 | Atlético San Luis | - | UANL Tigres | 0:3 | ||||
| 12. Jornada | 03.10.2021 | Club León | - | Atlético San Luis | 0:0 | ||||
| 13. Jornada | 17.10.2021 | Atlético San Luis | - | CF América | 0:1 | ||||
| 15. Jornada | 25.10.2021 | Atlético San Luis | - | Atlas Guadalajara | 2:6 | ||||
| 16. Jornada | 01.11.2021 | Atlético San Luis | - | CF Monterrey | 1:1 | ||||
| 5. Jornada | 04.11.2021 | CF Pachuca | - | Atlético San Luis | 0:0 | ||||
| 17. Jornada | 08.11.2021 | Santos Laguna | - | Atlético San Luis | 0:0 |
México