| 1. Jornada | 07.01.2022 | Atlético San Luis | - | CF Pachuca | 0:2 | ||||
| 2. Jornada | 16.01.2022 | Atlas Guadalajara | - | Atlético San Luis | 1:0 | ||||
| 3. Jornada | 21.01.2022 | Atlético San Luis | - | FC Juárez | 0:1 |  |
|||
| 5. Jornada | 13.02.2022 | Atlético San Luis | - | Deportivo Toluca | 0:1 | ||||
| 6. Jornada | 20.02.2022 | UANL Tigres | - | Atlético San Luis | 2:1 | ||||
| 7. Jornada | 27.02.2022 | CF Monterrey | - | Atlético San Luis | 0:2 | ||||
| 8. Jornada | 03.03.2022 | Atlético San Luis | - | Deportivo Guadalajara | 2:2 | ||||
| 10. Jornada | 14.03.2022 | Atlético San Luis | - | Puebla FC | 2:1 | ||||
| 11. Jornada | 18.03.2022 | Gallos Blancos | - | Atlético San Luis | 2:1 | ||||
| 12. Jornada | 02.04.2022 | Atlético San Luis | - | Mazatlán FC | 1:0 | ||||
| 9. Jornada | 07.04.2022 | Club Tijuana | - | Atlético San Luis | 1:1 |  |
|||
| 13. Jornada | 10.04.2022 | Atlético San Luis | - | Club León | 2:0 | ||||
| 14. Jornada | 16.04.2022 | Club Necaxa | - | Atlético San Luis | 4:2 | ||||
| 15. Jornada | 21.04.2022 | Atlético San Luis | - | Pumas UNAM | 2:0 | ||||
| 16. Jornada | 25.04.2022 | Cruz Azul | - | Atlético San Luis | 0:1 | |
|||
| 17. Jornada | 01.05.2022 | Atlético San Luis | - | Santos Laguna | 1:3 |
México