| 2. Jornada | 21.01.2021 | Montevideo Wanderers | - | Danubio | 2:0 | ||||
| 3. Jornada | 31.01.2021 | Danubio | - | Peñarol | 0:1 |  |
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| 4. Jornada | 04.02.2021 | River Plate | - | Danubio | 0:4 |  |
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| 5. Jornada | 07.02.2021 | Danubio | - | Montevideo City Torque | 0:4 | |
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| 6. Jornada | 10.02.2021 | Plaza Colonia | - | Danubio | 3:0 | ||||
| 8. Jornada | 18.02.2021 | Fénix | - | Danubio | 1:1 | |
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| 12. Jornada | 13.03.2021 | Danubio | - | Nacional | 2:1 | |
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| 13. Jornada | 19.03.2021 | Boston River | - | Danubio | 1:5 | |
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| 15. Jornada | 29.03.2021 | Rentistas | - | Danubio | 1:0 | |
Uruguay