| 1. Jornada | 08.08.2021 | ADO Den Haag | - | Jong Ajax | 2:0 | ||||
| 2. Jornada | 16.08.2021 | Jong Ajax | - | FC Dordrecht | 1:2 | ||||
| 4. Jornada | 27.08.2021 | Jong Ajax | - | SBV Excelsior | 1:2 |  |
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| 9. Jornada | 01.10.2021 | Helmond Sport | - | Jong Ajax | 3:1 | ||||
| 11. Jornada | 15.10.2021 | Jong Ajax | - | FC Utrecht (J) | 3:1 | ||||
| 12. Jornada | 22.10.2021 | FC Eindhoven | - | Jong Ajax | 1:3 | ||||
| 14. Jornada | 05.11.2021 | VVV-Venlo | - | Jong Ajax | 1:3 | |
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| 16. Jornada | 19.11.2021 | Jong Ajax | - | FC Volendam | 4:4 | |
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| 15. Jornada | 22.11.2021 | Jong Ajax | - | Roda JC Kerkrade | 2:1 | ||||
| 18. Jornada | 06.12.2021 | Jong Ajax | - | FC Emmen | 1:0 | ||||
| 19. Jornada | 10.12.2021 | TOP Oss | - | Jong Ajax | 1:1 | ||||
| 20. Jornada | 20.12.2021 | Jong Ajax | - | Helmond Sport | 1:1 | ||||
| 22. Jornada | 17.01.2022 | Jong Ajax | - | FC Den Bosch | 2:1 | ||||
| 25. Jornada | 04.02.2022 | Jong Ajax | - | AZ Alkmaar (J) | 2:1 | ||||
| 26. Jornada | 11.02.2022 | SBV Excelsior | - | Jong Ajax | 6:2 | ||||
| 27. Jornada | 21.02.2022 | Jong Ajax | - | Almere City FC | 1:3 | ||||
| 32. Jornada | 04.04.2022 | Jong Ajax | - | TOP Oss | 4:1 | ||||
| 38. Jornada | 06.05.2022 | Jong Ajax | - | De Graafschap | 1:1 |
Países Bajos